A new study involving 237 free-ranging rhesus macaques has provided compelling molecular evidence that early-life adversity markedly affects the epigenome and biological aging across multiple tissues. Researchers from Arizona State University and Vanderbilt University utilized tissue-specific epigenetic clocks to analyze how childhood experiences, like maternal loss or social stress, correlate with DNA methylation changes in adulthood. They discovered that while adversity-related changes can resemble accelerated aging in some genomic areas, they can also have opposite effects, challenging the notion that early trauma universally speeds up aging. This research emphasizes the complexity of aging, which varies significantly between tissues and highlights the importance of examining multiple tissues instead of relying solely on blood samples for understanding health outcomes.
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Link to original article source: https://neurosciencenews.com/early-adversity-multi-tissue-epigenetics-30922/
